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. Author manuscript; available in PMC: 2018 Jul 7.
Published in final edited form as: Eur J Med Chem. 2017 Mar 30;134:185–206. doi: 10.1016/j.ejmech.2017.03.069

Table 2.

HDAC class I cellular activity and in vitro antiproliferative activity for synthesized HDAC inhibitors 11a-11g.a

graphic file with name nihms968787u1.jpg
Cpd No. Structure IC50 of HDAC cellular class I (μM)b IC50 of HL60 cell (μM)
11a graphic file with name nihms968787t9.jpg 0.67 1.84
11b graphic file with name nihms968787t10.jpg 1.51 2.38
11c graphic file with name nihms968787t11.jpg 1.98 3.09
11d graphic file with name nihms968787t12.jpg 1.61 6.09
11e graphic file with name nihms968787t13.jpg 1.02 5.85
11f graphic file with name nihms968787t14.jpg 0.78 1.74
11g graphic file with name nihms968787t15.jpg 0.91 2.40
a

Assays were performed in HL60 cells; Values are average of at least two determinations, the SD values are < 20% of the mean.

b

Boc-Lys (acetyl)-AMC substrate.