Skip to main content
. Author manuscript; available in PMC: 2018 Jul 7.
Published in final edited form as: Eur J Med Chem. 2017 Mar 30;134:185–206. doi: 10.1016/j.ejmech.2017.03.069

Table 3.

In Vitro inhibition of HDACs isoforms of representative Compounds.a

graphic file with name nihms968787u2.jpg
Cpd No. R1 IC50 (nM)
HDAC1 HDAC2 HDAC3
3 graphic file with name nihms968787t16.jpg 49.6 441 227
11a graphic file with name nihms968787t17.jpg 20.6 157 138
19 graphic file with name nihms968787t18.jpg 58.6 296 42.9
30a graphic file with name nihms968787t19.jpg 14.7 111 90.0
30b graphic file with name nihms968787t20.jpg >20000 >20000 >20000
22 graphic file with name nihms968787t21.jpg 284 217 261
37 graphic file with name nihms968787t22.jpg 29.9 21.2 223
a

Assays were performed in replicate (n ≥ 2); The SD values are < 20% of the mean.