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. Author manuscript; available in PMC: 2018 Jul 7.
Published in final edited form as: Eur J Med Chem. 2017 Mar 30;134:185–206. doi: 10.1016/j.ejmech.2017.03.069

Table 8.

In Vitro inhibition of HDACs isoforms of representative compounds 43a and 49.a

Cpd No. Class I (μΜ)
Class IIa (μΜ)
Class IIb (μΜ)
HDAC1 HDAC2 HDAC3 HDAC8 HDAC4 HDAC6
43a 0.048 0.337 3.57 >100 >100 >100
49 0.511 0.908 0.110 >100 >100 >100
11r[17] 0.012 0.50 0.004 2.0 5.7 0.31
a

Assays were performed in replicate (n ≥ 2); The SD values are < 20% of the mean.