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In Vitro Antiproliferative Activity of representative and MS275.a
| Cpd | IC50 (μΜ)a
|
|||||
|---|---|---|---|---|---|---|
| HEL | K562 | U937 | U266 | HCT116 | ES-2 | |
| 10 | 15.4 | 8.51 | 13.20 | 12.7 | 10.6 | >20 |
| 43a | 16.6 | 16.0 | >20 | >20 | >20 | >20 |
| 43b | 25.2 | 15.7 | >20 | >20 | >20 | >20 |
| 11a | 3.02 | 0.98 | 1.10 | 2.23 | 4.23 | >20 |
| 56b | >20 | 13.5 | >20 | >20 | >20 | >20 |
| 56c | >20 | 14.0 | >20 | >20 | >20 | >20 |
| MS275 | 1.29 | 1.68 | 0.77 | 6.10 | 2.07 | >20 |
Assays were performed in replicate (n ≥ 2); The SD values are < 20% of the mean.
