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. Author manuscript; available in PMC: 2018 Jun 11.
Published in final edited form as: J Med Chem. 2008 Jan 18;51(3):603–611. doi: 10.1021/jm070910s

Figure 2.

Figure 2

Proposed binding mode of serotonin (5-HT; 1) in the h5-HT6 receptor, looking through the extracellular side of the helical bundle. TM5, TM6 and TM7 are nearest to the viewer. The backbone ribbon trace is color-coded based on the assignment of secondary structure using the Kabsch-Sander29 algorithm (red = helix, blue = sheet, violet = turn, and yellow = coil). 5-HT (1) is rendered as a CPK-style space-filling model, and the side chains of residues whose heavy atoms fall within 4.0 Å of the ligand’s heavy atoms are rendered as capped sticks.