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. Author manuscript; available in PMC: 2018 Jun 11.
Published in final edited form as: J Med Chem. 2008 Jan 18;51(3):603–611. doi: 10.1021/jm070910s

Figure 3.

Figure 3

Proposed binding mode of MS-245 (4a) in the h5-HT6 receptor, looking through the extracellular side of the helical bundle. TM5, TM6 and TM7 are nearest to the viewer. The MS-245 ligand is rendered as a ball-and-stick model with the carbon backbone in green, and the side chains of residues whose heavy atoms fall within 4.0 Å of the ligand’s heavy atoms are rendered as capped sticks.