Table 2.
Univariate and multivariate analyses for of CSS predictors in men with hormone receptor-positive breast cancer.
| Variables | 5-year CSS (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Log Rank χ2 test | P value | HR | 95% CI | P value | ||
| Marital status | 28.501 | <0.0001 | ||||
| Married | 90.8 | Reference | ||||
| Unmarried | 83.8 | 1.394 | 1.153–1.687 | 0.001 | ||
| Age | 1.214 | 0.545 | ||||
| <50 | 89.8 | Reference | ||||
| 50–64 | 91.0 | 0.950 | 0.728–1.238 | 0.702 | ||
| ≥65 | 87.0 | 1.203 | 0.925–1.566 | 0.169 | ||
| Race | 37.467 | <0.0001 | ||||
| White | 89.9 | Reference | ||||
| Black | 79.9 | 1.731 | 1.369–2.189 | <0.0001 | ||
| Other | 91.5 | 0.935 | 0.617–1.417 | 0.753 | ||
| Residence type | 0.734 | 0.693 | ||||
| Metropolitan | 89.1 | |||||
| Non-metropolitan | 86.4 | |||||
| Histology | 16.697 | <0.0001 | ||||
| Ductal | 88.1 | Reference | ||||
| Lobular | 92.4 | 0.761 | 0.240–2.412 | 0.642 | ||
| Others | 93.9 | 0.600 | 0.416–0.867 | 0.007 | ||
| Grade | 55.794 | <0.0001 | ||||
| Well/moderately differentiated | 92.1 | Reference | ||||
| Poorly/undifferentiated | 82.8 | 1.611 | 1.336–1.942 | <0.0001 | ||
| Pathologic T stage | 69.301 | <0.0001 | ||||
| T0–T1 | 96.5 | Reference | ||||
| T2 | 84.9 | 2.199 | 1.577–3.067 | <0.0001 | ||
| T3 | 77.2 | 2.838 | 1.649–4.883 | <0.0001 | ||
| Pathologic N stage | 313.683 | <0.0001 | ||||
| N0 | 95.2 | Reference | ||||
| N1 | 88.7 | 2.366 | <0.0001 | |||
| N2 | 79.4 | 4.235 | <0.0001 | |||
| N3 | 67.7 | 6.261 | <0.0001 | |||
| ER status | 0.156 | 0.925 | ||||
| Negative | 89.2 | |||||
| Positive | 88.9 | |||||
| PR status | 26.386 | <0.0001 | ||||
| Negative | 84.2 | Reference | ||||
| Positive | 89.3 | 0.669 | 0.531–0.844 | 0.001 | ||
| HER2 status | 6.467 | 0.039 | ||||
| Negative | 93.1 | Reference | ||||
| Positive | 83.8 | 1.316 | 0.575–3.012 | 0.516 | ||
| Surgery | 57.175 | <0.0001 | ||||
| No | 74.2 | Reference | ||||
| Yes | 90.3 | 0.505 | 0.290–0.880 | 0.016 | ||
| Radiation | 17.788 | <0.0001 | ||||
| No | 90.1 | Reference | ||||
| Yes | 85.3 | 0.982 | 0.802–1.203 | 0.860 | ||
CI – confidence interval; CSS – cause-specific survival; ER – estrogen receptor; HER2 – human epidermal growth factor receptor 2; R – hazard ratio; PR – progesterone receptor.