Table 3.
Univariate and multivariate analyses of OS predictors in men with hormone receptor-positive breast cancer.
| Variables | 5-year OS (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Log Rank χ2 test | P value | HR | 95% CI | P value | ||
| Marital status | 79.335 | <0.0001 | ||||
| Married | 78.6 | Reference | ||||
| Unmarried | 64.2 | 1.548 | 1.373–1.746 | <0.0001 | ||
| Age | 280.203 | <0.0001 | ||||
| <50 | 86.9 | Reference | ||||
| 50–64 | 85.4 | 1.167 | 0.930–1.464 | 0.182 | ||
| ≥65 | 64.0 | 3.126 | 2.534–3.857 | <0.0001 | ||
| Race | 18.314 | <0.0001 | ||||
| White | 74.9 | Reference | ||||
| Black | 67.4 | 1.378 | 1.166–1.629 | <0.0001 | ||
| Other | 82.5 | 0.791 | 0.601–1.043 | 0.097 | ||
| Residence type | 1.771 | 0.412 | ||||
| Metropolitan | 74.6 | |||||
| Non-metropolitan | 72.7 | |||||
| Histology | 12.566 | 0.002 | ||||
| Ductal | 73.5 | Reference | ||||
| Lobular | 92.4 | 0.435 | 0.179–1.056 | 0.066 | ||
| Others | 80.2 | 0.825 | 0.679–1.001 | 0.052 | ||
| Grade | 35.760 | <0.0001 | ||||
| Well/moderately differentiated | 78.8 | Reference | ||||
| Poorly/undifferentiated | 66.5 | 1.327 | 1.175–1.498 | <0.0001 | ||
| Pathologic T stage | 113.607 | <0.0001 | ||||
| T0–T1 | 87.4 | Reference | ||||
| T2 | 68.0 | 1.858 | 1.531–2.255 | <0.0001 | ||
| T3 | 58.9 | 2.363 | 1.680–3.324 | <0.0001 | ||
| Pathologic N stage | 470.864 | <0.0001 | ||||
| N0 | 85.2 | Reference | ||||
| N1 | 74.4 | 1.669 | 1.444–1.930 | <0.0001 | ||
| N2 | 66.0 | 2.479 | 2.035–3.019 | <0.0001 | ||
| N3 | 58.6 | 2.805 | 2.226–3.534 | <0.0001 | ||
| ER status | 0.265 | 0.876 | ||||
| Negative | 76.1 | |||||
| Positive | 74.5 | |||||
| PR status | 8.173 | 0.017 | ||||
| Negative | 71.6 | Reference | ||||
| Positive | 74.5 | 0.870 | 0.738–1.026 | 0.098 | ||
| HER2 status | 9.636 | 0.008 | ||||
| Negative | 76.7 | Reference | ||||
| Positive | 66.1 | 1.625 | 1.019–2.591 | 0.041 | ||
| Surgery | 109.767 | <0.0001 | ||||
| No | 39.7 | Reference | ||||
| Yes | 77.1 | 0.694 | 0.494–0.976 | 0.036 | ||
| Radiation | 0.113 | 0.737 | ||||
| No | 74.0 | Reference | ||||
| Yes | 75.8 | 0.824 | 0.717–0.947 | 0.006 | ||
CI – confidence interval; ER – estrogen receptor; HER2 – human epidermal growth factor receptor 2; HR – hazard ratio; OS – overall survival; PR – progesterone receptor.