Table 5.
Univariate and multivariate analyses of CSS predictors in 1: 1 matched groups of men with breast cancer.
| Variables | 5-year CSS (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Log Rank χ2 test | P value | HR | 95% CI | P value | ||
| Marital status | 4.730 | 0.030 | ||||
| Married | 87.4 | Reference | ||||
| Unmarried | 84.3 | 1.273 | 1.021–1.586 | 0.032 | ||
| Age | 1.737 | 0.420 | ||||
| <50 | 88.8 | Reference | ||||
| 50–64 | 86.7 | 1.028 | 0.754–1.401 | 0.863 | ||
| ≥65 | 84.2 | 1.203 | 0.882–1.641 | 0.242 | ||
| Race | 12.183 | 0.007 | ||||
| White | 87.0 | Reference | ||||
| Black | 80.6 | 1.475 | 1.130–1.926 | 0.004 | ||
| Other | 84.9 | 0.889 | 0.454–1.744 | 0.733 | ||
| Residence type | 1.899 | 0.387 | ||||
| Metropolitan | 86.4 | |||||
| Non-metropolitan | 81.5 | |||||
| Histology | 7.669 | 0.022 | ||||
| Ductal | 85.0 | Reference | ||||
| Lobular | 85.7 | 1.358 | 0.187–9.867 | 0.762 | ||
| Others | 90.9 | 0.749 | 0.505–1.109 | 0.149 | ||
| Grade | 28.095 | <0.0001 | ||||
| Well/moderately differentiated | 89.0 | Reference | ||||
| Poorly/undifferentiated | 79.4 | 1.438 | 1.142–1.811 | 0.002 | ||
| Pathologic T stage | 27.715 | <0.0001 | ||||
| T0–T1 | 94.0 | Reference | ||||
| T2 | 81.2 | 1.879 | 1.248–2.828 | 0.003 | ||
| T3 | 76.6 | 2.370 | 1.287–4.365 | 0.006 | ||
| Pathologic N stage | 169.063 | <0.0001 | ||||
| N0 | 92.9 | Reference | ||||
| N1 | 85.3 | 2.354 | 1.728–3.207 | <0.0001 | ||
| N2 | 77.6 | 3.979 | 2.764–5.727 | <0.0001 | ||
| N3 | 67.1 | 5.452 | 3.745–7.939 | <0.0001 | ||
| ER status | 0.519 | 0.772 | ||||
| Negative | 90.8 | |||||
| Positive | 85.8 | |||||
| PR status | 8.441 | 0.015 | ||||
| Negative | 85.0 | Reference | ||||
| Positive | 85.6 | 0.743 | 0.555–0.995 | 0.046 | ||
| HER2 status | 5.322 | 0.070 | ||||
| Negative | 90.9 | Reference | ||||
| Positive | 77.3 | 1.448 | 0.581–3.608 | 0.427 | ||
| Surgery | 30.247 | <0.0001 | ||||
| No | 71.5 | Reference | ||||
| Yes | 87.0 | 0.438 | 0.227–0.848 | 0.014 | ||
| Radiation | 11.689 | 0.001 | ||||
| No | 87.1 | Reference | ||||
| Yes | 82.7 | 1.054 | 0.821–1.352 | 0.681 | ||
CI – confidence interval; CSS – cause-specific survival; ER – estrogen receptor; HER2 – human epidermal growth factor receptor 2; HR – hazard ratio; PR – progesterone receptor.