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. 2018 May 17;16(1):171–177. doi: 10.3892/etm.2018.6181

Figure 1.

Figure 1.

Effect of IL-31 on experimental sepsis. (A) Survival rate of IL-31-treated or PBS-treated (vehicle control) mice with LPS-induced sepsis. (B) Proinflammatory cytokine production in the sera from each group. (C) IL-31 level in the peritoneal lavage fluid of mice with LPS-induced sepsis and normal mice without LPS treatment. (D) IL-1β level in the peritoneal lavage fluid of mice with LPS-induced sepsis in the presence or absence of IL-31 injection. (E) IL-1β level in the peritoneal lavage fluid of mice with CLP-induced sepsis in the presence or absence of IL-31 injection. *P=0.0473 vs. PBS from 24 to 72 h; **P<0.01 and ***P<0.001, as indicated. Experiments were performed in triplicate. IL, interleukin; PBS, phosphate-buffered saline; LPS, lipopolysaccharide; TNF, tumor necrosis factor; CLP, cecal ligation and puncture.