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. 2018 May 17;16(1):171–177. doi: 10.3892/etm.2018.6181

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Copyright: © Gu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — In vitro role of IL-31 on IL-1β activation. (A) Expression of IL-31 and IL-31RA on the peritoneal macrophage with or without ATP stimulation. (B) Expression of NLRP3 on peritoneal macrophages with or without IL-31 treatment under ATP stimulation. (C) Secretion of IL-1β on peritoneal macrophage supernatant with or without IL-31 treatment under ATP stimulation. (D) Expression of NLRP3 on the THP-1 cell with anti-IL-31 antibody or anti-IL-31RA antibody treatment under ATP stimulation plus IL-31. (E) Secretion of cytokines in THP-1 cell supernatant with anti-IL-31RA antibody treatment under ATP stimulation plus IL-31. **P<0.01 and ***P<0.001, as indicated. Experiments were performed in triplicate. IL, interleukin; IL-31RA, interleukin-31 receptor A; ATP, adenosine triphosphate; PBS, phosphate-buffered saline.