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. 2018 Jun 4;5:116. doi: 10.3389/fvets.2018.00116

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Copyright © 2018 Ilyinskaya, Mukhina, Soboleva, Matveeva and Chumakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oncolytic Sendai virus MCT treatments results (Cases 3 and 4). Case 3. Male dog of mixed breed of 10 years old was presented with subcutaneous, distant (stage 4) poorly differentiated MCT located on abdomen with multiple palpable metastases. A debulking surgery has been performed. (1) Primary tumor before surgery (120 mm in diameter); (2) MCT secondary growth along the surgical scar, 4 days after the surgery; (3) MCT site, 1 week after the first viral treatment; (4) MCT site, 4 weeks after the first virus treatment. Case 4. Female dog of mixed breed of 8.5 years old was presented with cutaneous, local (stage 1) intermediately differentiated MCT. (1) Primary tumor (35 mm in diameter) before any treatment; (2) MCT site after complete surgical removal with at least 5 mm clean margins; (3) MCT relapse, 6 weeks after the surgery; (4) MCT site, 1 week after the first viral treatment; (5) MCT site, 2 weeks after the first virus treatment.