Table 1.

Aberrations in physiology and behavior associated with neuropsychiatric illness that are detectable by sensors in smartphones and wearables

	Sensor type
Illness	Accelerometry	HR	GPS	Calls & SMS
Stress & depression	Disruptions in circadian rhythm and sleep	Emotion mediates vagal tone which manifests as altered HRV	Irregular travel routine	Decreased social interactions
Bipolar disorder	Disruptions in circadian rhythm and sleep, locomotor agitation during manic episode	ANS dysfunction via HRV measures	Irregular travel routine	Decreased or increased social interactions
Schizophrenia	Disruptions in circadian rhythm and sleep, locomotor agitation or catatonia, diminished overall activity	ANS dysfunction via HRV measures	Irregular travel routine	Decreased social interactions
PTSD	Inconclusive evidence	ANS dysfunction via HRV measures	Inconclusive evidence	Decreased social interactions
Dementia	Dementia Disruptions in circadian rhythm, diminished locomotor activity	Inconclusive evidence	Wandering away from home	Decreased social interaction
Parkinson’s disease	Gait impairment, ataxia, dyskinesia	ANS dysfunction via HRV measures	Inconclusive evidence	Voice features can indicate vocal impairment