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. Author manuscript; available in PMC: 2018 Jun 11.
Published in final edited form as: Chem Res Toxicol. 2018 Apr 19;31(5):358–370. doi: 10.1021/acs.chemrestox.8b00056

Figure 3.

Figure 3

Representative chromatograms obtained from the LC-ESI+-MS/MS analyses of (A) POB- and (B) PHB-DNA adducts in the lungs of rats chronically treated with 5 ppm NNK for 50 weeks. In each case, the top two channels are monitoring separate transitions for the N1-dIno adducts (POB: m/z 400 → m/z 284, 148; PHB: m/z 402 → m/z 286, 132). The bottom two channels are monitoring the N6-dAdo adducts (POB: m/z 399 → m/z 265; PHB: m/z 401 → m/z 132) and its isotopically-labeled internal standard (POB: m/z 403 → m/z 269; PHB: m/z 406 → m/z 132).