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. Author manuscript; available in PMC: 2018 Jun 11.
Published in final edited form as: Chem Res Toxicol. 2018 Apr 19;31(5):358–370. doi: 10.1021/acs.chemrestox.8b00056

Table 1.

Levels of DNA adducts in lung and liver DNA from rats chronically treated with NNK, (S)-NNAL, or (R)-NNAL (5 ppm in their drinking water) for 50 weeks. Values are the average of three replicates and their standard deviations.

Tissue Treatment N6-POB-dAdo (fmol/mg DNA) O6-POB-dGuo (fmol/mg DNA) 7-POB-Gua (fmol/mg DNA) O2-POB-Thd (fmol/mg DNA) O2-POB-Cyt (fmol/mg DNA)
Liver NNK 32 ± 9 < LOQa 257 ± 32a 1531 ± 161a < LOQ
(S)-NNAL 27 ± 6 < LOQ 356 ± 18 1680 ± 100 < LOQ
(R)-NNAL 4 ± 1 < LOQ 28 ± 5 130 ± 27 < LOQ
Lungb NNK 99 ± 3 9 ± 2 688 ± 65 4409 ± 320 < LOQ
(S)-NNAL 130 ± 1 10 ± 5 568 ± 68 3951 ± 328 < LOQ
(R)-NNAL 16 ± 7 < LOQ 136 ± 10 584 ± 45 < LOQ

N6-PHB-dAdo (fmol/mg DNA) O6-PHB-dGuo (fmol/mg DNA) 7-PHB-Gua (fmol/mg DNA) O2-PHB-Thd (fmol/mg DNA)

Liver NNK 6 ± 1 < LOQ 295 ± 42 658 ± 107
(S)-NNAL 5 ± 1 < LOQ 133 ± 15 422 ± 36
(R)-NNAL 24 ± 2 < LOQ 436 ± 23 2995 ± 121
Lungb NNK 35 ± 5 < LOQ 129 ± 34 1259 ± 66
(S)-NNAL 36 ± 8 < LOQ 100 ± 25 1152 ± 41
(R)-NNAL 125 ± 34 < LOQ 379 ± 19 6291 ± 885
a

Selected data are from Balbo et al (2014)18

b

DNA adduct data other than N6-dAdo is from Ma et al (2017)19