Table 1.
Tissue | Treatment | N6-POB-dAdo (fmol/mg DNA) | O6-POB-dGuo (fmol/mg DNA) | 7-POB-Gua (fmol/mg DNA) | O2-POB-Thd (fmol/mg DNA) | O2-POB-Cyt (fmol/mg DNA) |
---|---|---|---|---|---|---|
Liver | NNK | 32 ± 9 | < LOQa | 257 ± 32a | 1531 ± 161a | < LOQ |
(S)-NNAL | 27 ± 6 | < LOQ | 356 ± 18 | 1680 ± 100 | < LOQ | |
(R)-NNAL | 4 ± 1 | < LOQ | 28 ± 5 | 130 ± 27 | < LOQ | |
Lungb | NNK | 99 ± 3 | 9 ± 2 | 688 ± 65 | 4409 ± 320 | < LOQ |
(S)-NNAL | 130 ± 1 | 10 ± 5 | 568 ± 68 | 3951 ± 328 | < LOQ | |
(R)-NNAL | 16 ± 7 | < LOQ | 136 ± 10 | 584 ± 45 | < LOQ | |
| ||||||
N6-PHB-dAdo (fmol/mg DNA) | O6-PHB-dGuo (fmol/mg DNA) | 7-PHB-Gua (fmol/mg DNA) | O2-PHB-Thd (fmol/mg DNA) | |||
|
||||||
Liver | NNK | 6 ± 1 | < LOQ | 295 ± 42 | 658 ± 107 | |
(S)-NNAL | 5 ± 1 | < LOQ | 133 ± 15 | 422 ± 36 | ||
(R)-NNAL | 24 ± 2 | < LOQ | 436 ± 23 | 2995 ± 121 | ||
Lungb | NNK | 35 ± 5 | < LOQ | 129 ± 34 | 1259 ± 66 | |
(S)-NNAL | 36 ± 8 | < LOQ | 100 ± 25 | 1152 ± 41 | ||
(R)-NNAL | 125 ± 34 | < LOQ | 379 ± 19 | 6291 ± 885 |