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. 2018 May 29;9(41):26507–26526. doi: 10.18632/oncotarget.25476

Figure 4. Notochordal cell-derived matrix (NCM) improves the macroscopic Thompson score and radiologic parameters of degenerated intervertebral discs (IVDs).

Figure 4

Median (Thompson (A), Pfirrmann (B)) and mean (Disc Height Index; DHI (D), T2 values (E)) values are indicated. (C) Macroscopic and MRI pictures of the canine IVDs. Change in DHI and T2 mapping values were calculated at individual intervertebral disc (IVD) level. NX: partial nucleus pulposus (NP) removal to induce moderate IVD degeneration. *,**p < 0.05, p < 0.01, respectively for the indicated condition versus control noNX-IVDs; #p = 0.05–0.15, large effect size, for the indicated condition versus control noNX-IVDs; $p = 0.05–0.15, large effect size, between indicated conditions; n = 5. For Thompson and Pfirrmann data, a Mann–Whitney Wilcoxon test and for DHI and quantitative T2 mapping, a Cox proportional hazard model (donor as random effect) was performed with Benjamini & Hochberg tests. For comparisons with 0.05 ≥ p ≤ 0.20, effect sizes (Cliff’s delta) were determined.