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. 2018 May 29;9(41):26507–26526. doi: 10.18632/oncotarget.25476

Figure 5. Notochordal cell-derived matrix (NCM) improves canine intervertebral disc (IVD) histology.

Figure 5

H&E and Picrosirius Red-Alcian Blue (blue: glycosaminoglycan, red: collagen) staining of canine nucleus pulposus tissue (A, B). Total histologic Boos score (C) and its subsets: chondrocyte-like (CLC) proliferation in the nucleus pulposus (NP; D), end plate morphology (E), and subchondral bone sclerosis (F). Median values are indicated. NX: partial NP removal to induce moderate IVD degeneration. n.s.: not significant; *p < 0.05 between indicated conditions; $p = 0.05–0.18 with medium-large effect size between indicated conditions; n = 5. Data were analyzed with Mann–Whitney Wilcoxon and Benjamini & Hochberg tests. For comparisons with 0.05 ≥ p ≤ 0.20, effect sizes (Cliff’s delta) were determined.