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. 2018 May 29;9(41):26417–26430. doi: 10.18632/oncotarget.25443

Figure 3. Prevalence of the selected common structural and short variants according to age subsets.

Figure 3

(A) Selected common structural variants (CDKN2A/B, KMT2A, NUP and RUNX1) were highly prevent in young patients and exceedingly rare in older patients (> 65 years), however AYA patients (age 16-40) demonstrated a profile unique both end of the age spectrum, but had a higher prevalence of structural variants than adult and older adult AML. (B) Selected common short variants (TET2, IDH1/2, SRSF2, U2AF1, and SF3B1) were rare or not detected in young patients and highly prevalent in older patients. Similarly to structural variants, AYA patients demonstrated a profile unique both end of the age spectrum, but many of the most commonly detected short variants detected in adult AML were rare in the AYA cohort, demonstrating that targeted agents for these alterations will have a low impact in the AYA cohort overall.