Figure 4. Retention of human immune cells in the blood and spleen of humanized mouse models.

Representative dot plots of pDCs (A and D) (lineage⁻, HLA-DR⁺, CD14^−/mid, CD14⁻, and CD123⁺), (B and E) CD4⁺ T cells, CD8⁺ T cells, B cells (CD19⁺), and (C and F) monocytes (CD14⁺/SSC^high) in the ST-model (first letters) and LT-model (second letters). The humanized mice were vaccinated according to the scheme in Figure 1, and 16 h after the vaccination, lungs were collected and applied to the flow-cytometric analyses. Dot plots indicate the rate of lymphocyte gating in each cell subset. Each circle represents a result from an individual animal, and horizontal bars indicate mean ± SD.