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. 2018 Jun 4;9:731. doi: 10.3389/fpls.2018.00731

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Copyright © 2018 He, Liang, Cong, Chen, Zhao, Zhao, Zhang, Wang, Dong, Yang, Zhang, Qian, Fan and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic tree of OMTs. Phylogenetic tree was constructed based on the deduced amino acid sequences from C. teeta and C. chinensis OMTs (triangles of different colors) and other plant OMTs. Abbreviations and GenBank accession numbers for the sequences used are as follows: EcOMT, putative E. californica OMT (ACO90220.1); CjCoOMT, C. japonica columbamine OMT (Q8H9A8.1); TtOMT, Thalictrum tuberosum catechol OMT (AAD29845.1); TtCaOMT, T. tuberosum catechol OMT (AAD29843.1); PsCaOMT, P. somniferum catechol OMT (AAQ01670.1); PsN7OMT, P. somniferum norreticuline 7OMT (ACN88562.1); Ps6OMT, P. somniferum norcoclaurine 6OMT (AAP45315.1); Ps4^′OMT2, P. somniferum 3^′-hydroxy-N-methylcoclaurine 4^′OMT2 (AAP45314.1); Ps4^′OMT1, P. somniferum 3^′-hydroxy-N-methylcoclaurine 4^′OMT1 (AAP45314.1); Cc4^′OMT, C. chinensis 3^′-hydroxy-N-methylcoclaurine 4^′OMT (ABY75613.1); Cj4^′OMT, C. japonica 3^′-hydroxy-N-methylcoclaurine 4^′OMT (Q9LEL5.1); Tf4^′OMT, T. flavum 3^′-hydroxy-N-methylcoclaurine 4^′OMT (AAU20768.1); Cj6OMT, C. japonica norcoclaurine 6OMT (Q9LEL6.1); Tf6OMT, T. flavum norcoclaurine 6OMT (AAU20765.1); VvReOMT, Vitis vinifera resveratrol OMT (CAQ76879.1); PtFlOMT, Populus trichocarpa flavonoid OMT predicted protein (XP_002312933.1); CjSOMT, C. japonica scoulerine 9OMT (Q39522.1); TfSOMT, T. flavum scoulerine 9OMT(AAU20770.1); PaCafOMT, Picea abies caffeate OMT (CAI30878.1); CaCafOMT, Capsicum annuum caffeate OMT (AAG43822.1); PsOMT1, P. somniferum SOMT1 (JN185323); PsOMT2, P. somniferum SOMT2 (JN185324); PsOMT3, P. somniferum SOMT3 (JN185325); ObEuOMT, Ocimum basilicum eugenol OMT (AAL30424.1); MpFlOMT, Mentha X piperita flavonoid 8OMT (AAR09600.1); ObCafOMT, O. basilicum caffeate OMT (AAD38189.1); CbEuOMT, Clarkia breweri (iso)eugenol OMT (AAC01533.1); CbCafOMT, C. breweri caffeate OMT (O23760.1); AmCafOMT, Ammi majus caffeate OMT (AAR24095.1); Ec7OMT, E. californica reticuline 7OMT (BAE79723.1); Ps7OMT, P. somniferum reticuline 7OMT (AAQ01668.1); Ec4^′OMT, E. californica 3^′-hydroxy-N-methylcoclaurine 4^′OMT (BAM37633.1); and Ec6OMT, E. californica OMT (BAM37634.1).