Table 2.
Top 10 independent SNPs that have the lowest association p-values for analyses examining genome-wide genetic variations and placental abruption risk among PAGE and Meta-analysis studies.
| Gene | Chr omo some |
SNP* | Effect Allele |
Effect Allele Frequency |
Odds
Ratio (95% Confidence Interval) |
Empirical p-value |
|---|---|---|---|---|---|---|
| PAGE Study | ||||||
| ABCC8 | 11 | rs4148646 | G | 0.633 | 0.67 (0.58,0.79) | 1.00E-06 |
|
| ||||||
| KCNJ11 | 11 | rs2074314 | T | 0.635 | 0.67 (0.58,0.79) | 1.40E-06 |
|
| ||||||
| ABCC8 | 11 | rs2074311 | G | 0.623 | 0.68 (0.58,0.80) | 1.90E-06 |
|
| ||||||
| ZNF28 | 19 | rs7249210 | A | 0.09 | 2.11 (1.54,2.87) | 3.00E-06 |
|
| ||||||
| KCNJ11 | 11 | rs35271178 | T | 0.623 | 0.69 (0.59,0.81) | 3.80E-06 |
|
| ||||||
| ZNF28 | 19 | rs7250184 | C | 0.091 | 2.09 (1.53,2.84) | 3.80E-06 |
|
| ||||||
| ZNF28 | 19 | rs7249100 | G | 0.091 | 2.08 (1.53,2.84) | 3.80E-06 |
|
| ||||||
| ZNF28 | 19 | rs10401828 | C | 0.093 | 2.05 (1.51,2.78) | 4.30E-06 |
|
| ||||||
| CTNND2 | 5 | rs11133659 | A | 0.088 | 2.12 (1.54,2.92) | 4.40E-06 |
|
| ||||||
| ZNF28 | 19 | rs146312 | T | 0.072 | 2.00 (1.49,2.70) | 5.30E-06 |
|
| ||||||
| Meta-analysis | ||||||
| IRX1 | 5 | rs76258369 | C | 0.164 | 1.56 (1.30,1.88) | 2.80E-06 |
|
| ||||||
| ADAM12 | 10 | rs7094759 | T | 0.482 | 0.74 (0.65,0.84) | 4.00E-06 |
|
| ||||||
| ADAM12 | 10 | rs12264492 | G | 0.404 | 0.73 (0.64,0.83) | 4.10E-06 |
|
| ||||||
| DOCK2 | 5 | rs30080 | C | 0.424 | 0.73 (0.63,0.83) | 5.00E-06 |
|
| ||||||
| PDGFRL | 8 | rs11995662 | C | 0.1 | 0.61 (0.49,0.75) | 5.20E-06 |
|
| ||||||
| KCNIP1 | 5 | rs4867606 | A | 0.099 | 1.82 (1.41,2.36) | 5.50E-06 |
|
| ||||||
| LOC105374318 | 2 | rs219551 | T | 0.142 | 1.64 (1.33,2.04) | 5.80E-06 |
|
| ||||||
| DOCK2 | 5 | rs7704841 | G | 0.422 | 0.73 (0.64,0.84) | 6.40E-06 |
|
| ||||||
| FAM196B | 5 | rs2291228 | G | 0.424 | 1.37 (1.19,1.56) | 7.90E-06 |
|
| ||||||
| GALNT13 | 2 | rs799758 | C | 0.176 | 1.47 (1.24,1.74) | 8.60E-06 |
|
| ||||||
| FAM124A | 13 | rs17837210 | C | 0.072 | 1.80 (1.39,2.33) | 8.60E-06 |
*
hg19 build 37 dbSNP