Extended Data Figure 3. Global activity of oncogenic signatures.

a. Activity of signatures is calculated relative to a normal tissue baseline, i.e. activity scores are compared to a compendium of 36 normal tissues. Therefore, this plot represents a comparison of pathway activities between metastatic tissues and normal tissues. Increased activity (positive difference, red) or decreased activity (negative difference, blue) indicates that the signature genes are on average more (or less) expressed in a metastatic tumor sample relative to the baseline (in average percentile point difference labeled “% diff activity”). Samples (columns) are ordered from left to right by decreasing average activity difference (column averages, i.e. the aggregate score in panel b) b. Boxplots summarizing the aggregate scores (column averages of “% diff activity”) in a. Analysis cohorts are ordered left-to-right by median aggregate scores.