Table 1.
WGCNA-based Clustering of DAC proteins across 16 brain regions.
Region | Region Abbreviation | Included Genes | Number of Modules | “Endfoot” Module | Genes in “Endfoot” module | “Candidate endfoot gene” in module |
---|---|---|---|---|---|---|
Primary auditory cortex | A1C | 8321 | 19 | Brown | 902 | AQP4, DTNA, SNTA1 |
Amygdaloid complex | AMY | 8537 | 20 | – | – | – |
Cerebellar cortex | CBC | 8514 | 26 | – | – | – |
Dorsolateral prefrontal Cortex | DFC | 8689 | 23 | Green | 544 | AQP4, DTNA, SNTA1 |
Hippocampus | HIP | 8639 | 19 | Cyan | 119 | AQP4, DTNA |
Posteroventral (inferior) parietal cortex | IPC | 8300 | 21 | Yellow | 697 | AQP4, DTNA, SNTA1 |
Inferolateral temporal cortex | ITC | 8437 | 23 | Green | 465 | AQP4, DTNA |
Primary motor cortex | M1C | 8551 | 16 | Yellow | 982 | AQP4, DTNA, SNTA1, DAG1 |
Mediodorsal nucleus of thalamus | MD | 7968 | 19 | Green | 700 | AQP4, SNTA1, DAG1 |
Anterior (rostral) cingulate cortex | MFC | 8447 | 19 | Red | 542 | AQP4, DTNA, SNTA1 |
Orbital frontal cortex | OFC | 8402 | 18 | Black | 416 | AQP4, DTNA, SNTA1 |
Primary somatosensory cortex | S1C | 8568 | 17 | Yellow | 921 | AQP4, SNTA1 |
Posterior (caudal) superior temporal cortex | STC | 8580 | 21 | Green | 613 | AQP4, SNTA1 |
Striatum | STR | 8620 | 27 | Pink | 388 | AQP4, DTNA |
Primary visual cortex | V1C | 8472 | 19 | Yellow | 841 | AQP4, DTNA, SNTA1 |
Ventrolateral prefrontal cortex | VFC | 8621 | 24 | Yellow | 588 | AQP4, DTNA, SNTA1 |
Summary of the clustering resulting from WGCNA of gene expression in each brain region. The cluster which contained the greatest number of candidate DAC genes is listed along with the genes that were associated with it.