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. 2018 May 8;10(5):1453–1463. doi: 10.1016/j.stemcr.2018.04.001

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© 2018 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Evidence for P53 Induction in Rett Patient Neurons in Human Brain

(A) Each Rett brain sample was assessed for the percentage of neurons with and without expression of MECP2 by immunostaining.

(B) RT-PCR on RNA isolated from Rett brain versus age-matched control brains for P53 targets.

(C) A re-analysis of data published by Gogliotti et al. (2018). Shown are a sample of P53 targets and SASP genes found on lists of genes upregulated in Rett brain. All of these differentially expressed genes were derived using a corrected p value (false discovery rate) <0.05 from at least n = 5 samples from control and Rett brains.

Bar graphs represent means ± SEM.