Table 2. Univariate and multivariate analysis model for overall survival.

Independent variables	Reference	Univariate model			Multivariate model
		Hazard ratio	95% CI	p-value	Hazard ratio	95% CI	p-value
T status
T2	T1	1.19	(1.08, 1.31)	< .001	1.16	(1.05, 1.27)	0.004
T3		2.47	(2.26, 2.69)	< .001	2.2	(2.01, 2.41)	< .001
T4		4.04	(3.48, 4.69)	< .001	3.53	(3.01, 4.14)	< .001
Histologic grade
2	Grade 1	1.39	(1.25, 1.54)	< .001	1.26	(1.14, 1.40)	< .001
3		2.29	(2.06, 2.54)	< .001	1.81	(1.62, 2.02)	< .001
4		2.19	(1.64, 2.92)	< .001	1.86	(1.39, 2.49)	< .001
Size
> = 5cm	Size < 5cm	1.4	(1.26, 1.56)	< .001	1.18	(1.06, 1.32)	0.003
Unknown		1.57	(1.42, 1.74)	< .001	1.37	(1.24, 1.52)	< .001
Node status
N1	N0	1.53	(1.40, 1.66)	< .001	1.28	(1.17, 1.40)	< .001
Nx		1.48	(1.36, 1.61)	< .001	1.26	(1.16, 1.37)	< .001
Histology
Papillary	Adenocarcinoma	0.52	(0.45, 0.60)	< .001	0.74	(0.64, 0.86)	< .001
Adenosquamous/Squamous		1.58	(1.36, 1.84)	< .001	1.29	(1.11, 1.50)	0.001
Surgery
Radical surgical resection
	Simple resection	1.07	(0.96, 1.19)	0.246	0.83	(0.74, 0.93)	0.002
Radiation
No radiation	Yes	1.12	(1.03, 1.22)	0.006	1.49	(1.36, 1.62)	< .001
Unknown		1.61	(1.26, 2.04)	< .001	1.93	(1.52, 2.46)	< .001