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. 2018 Jun 6;11:3345–3357. doi: 10.2147/OTT.S162470

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© 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited

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The changes in the intracellular levels of 3-PG and 2-PG, the cellular morphologies, and the migration and invasion abilities of pancreatic cancer cells after silencing PGAM1 by siRNA.

Notes: (A) Silencing PGAM1 in PC-1.0, Aspc-1, PC-1, and Capan-2 cells reflected by Western blot. (B) Increased intracellular level of 3-PG after silencing PGAM1. (C) Decreased intracellular level of 2-PG after silencing PGAM1. (D) Morphologic changes of pancreatic cancer cell lines (PC-1.0, Aspc-1, PC-1, and Capan-2) after silencing PGAM1. (E) Silencing PGAM1 inhibited migration and invasion of PC-1.0 and Aspc-1 cells reflected by Transwell invasion assay. (F) Silencing PGAM1 inhibited migration and invasion of PC-1 and Capan-2 cells reflected by Transwell invasion assay (P<0.05, Student’s t-test) (*p<0.05, **p<0.01).

Abbreviations: 3-PG, 3-phosphoglycerate; 2-PG, 2-phosphoglycerate.