Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 26;293(23):8969–8981. doi: 10.1074/jbc.RA117.001167

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

Figure 3. — Hyperosmotic induction of COX-2 is mediated by p38, but not by ERK or JNK. A and B, phospho-p38 (p-p38) levels significantly increase in response to hyperosmolarity. C and D, hyperosmotic increase of COX-2 mRNA is completely suppressed by p38 inhibitor, SB202190, but unaffected by JNK inhibitor, SP600125, and MEK/ERK inhibitor, PD98059. E, Western blot images showing that p38 inhibition prevents COX-2 induction in response to hyperosmolarity. F, Western blot images showing that ionomycin/PMA (I + P)-mediated COX-2 induction is not affected by p38 inhibition. G, densitometry analyses of Western blots shown in E and F. All the quantitative data are represented as mean ± S.D. from at least three independent experiments (three biological replicates). NS: nonsignificant; *, p < 0.05. PD: PD98059 (MEK/ERK inhibitor); SB90: SB202190 (p38 inhibitor); SP: SP600125 (JNK inhibitor).