Table 1.
Gating modifier toxin inhibition of voltage-gated sodium channels
Percentage inhibition of sodium currents was measured using TEVC electrophysiology, and EC50 values are mean ± S.E. (n = 3).
| Peptide | EC50 |
|||
|---|---|---|---|---|
| NaV1.2 | NaV1.4 | NaV1.5 | NaV1.6 | |
| nm | ||||
| ProTx-I | 59.7 ± 7.4 | 108.6 ± 19.3 | 76.3 ± 9.1 | 133 ± 10 |
| CcoTx-I | 6.1 ± 0.7 | 263 ± 45 | 188 ± 20 | 40.6 ± 5.8 |
| PaurTx-III | 0.70 ± 0.07 | 92.9 ± 12.7 | 46.3 ± 8.8 | 20.0 ± 2.1 |
| CcoTx-II | 3.7 ± 0.6 | 113 ± 24 | 1524 ± 58 | 49.9 ± 7.1 |
| GsMTx-IV | >3 μm | >3 μm | >10 μm | >3 μm |
| SgTx-Ia | >3 μm | >10 μm | >10 μm | >3 μm |
| HwTx-IV | 116 ± 16 | >10 μm | >10 μm | 117 ± 21 |
| HnTx-IV | 22.4 ± 3.0 | >10 μm | >10 μm | 50.1 ± 7.4 |
| GpTx-I | 128 ± 12 | >10 μm | >10 μm | 20.1 ± 1.7 |
a Values for SgTx-I are I30 ms/Ipeak because this GMT displayed a delay in channel inactivation accompanied by an increase in current.