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. 2018 May 1;4:4. doi: 10.1186/s40959-018-0030-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Plasma profiling for specific determinants of inflammation and signaling. a Plasma profiling for specific determinants of inflammation and ECM remodeling were examined in referent normal subjects and those undergoing initial AC treatment, designated here as Visit 1 in tabular format. The plasma TIMP-1 and 2 levels at this AC treatment time point were not different from referent controls, and while IL-10 and IL-8/IL-10 ratios fell in the AC treatment group at Visit 1, these did not reach statistical significance. b Due to the high incidence of plasma TIMP-3 and TIMP-4 levels were fell below analytical detection limits, a categorical analysis was performed using a Chi Square analysis. A significant shift in the proportion of detectable TIMP-3 and TIMP-4 in plasma samples taken from the initial AC treatment time point occurred (*p < 0.05). c In contrast to the analyte shown in Table A, significant shifts in plasma MMP-2, − 7 and − 9 occurred at AC treatment Visit 1 when compared to referent control values (*p < 0.05)