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. 2018 May 1;4:4. doi: 10.1186/s40959-018-0030-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Plasma profiling changes from Visit 1 to last available visit in AC treated patients. The relative change in ECM and inflammatory pathways were computed as a function of Visit 1 and the final visit in the AC treated patients. Those with a significant shift from Visit 1 are shown here and identify that continued shifts in determinants of inflammatory signaling and ECM remodeling occurred at later AC treatment time points. (*p < 0.05 vs Visit 1 values)