Table 2.

LV Parameter trends (medians) by Cardiac Magnetic Resonance Imaging

Cumulative AC Dose (mg/m2)	High dose group (n = 3)							Low dose group (n = 10)
	30–60	125–175	200–250	275–325	After Max	1 Year After	p	30–60	125–175	After Max	1 Year After	p
LV EF (%)	66.8	61.2	58.7	57.6	55.8	55.3	.005	62.6	60.8	60.4	57.9	.11
LV EF z score	0.57	−0.62	−1.1	−1.4	−1.7	−1.9	.005	−0.3	−0.6	−0.8	−1.3	.11
LV EVDI (ml/m2)	96.6	85.3	100.6	97.1	74.8	94.1	.22	75.6	78.3	73.9	78.3	.56
LV ESVI (ml/m2)	23.5	33.2	40.3	41.1	31.8	41.5	.30	29.3	30.7	29.9	33.0	.58
LV SV (ml)	132.3	88.5	87	85.6	77.5	99.2	.35	73.4	67.5	73.9	67.6	.93
LV Mass (g/m2)	133	107.1	135	128	122	135.8	.62	88.9	79.0	83	87.0	.87
LV Mass z score	0.4	0.7	0.2	0.5	0.3	0.6	.42	0.6	0	−0.2	−0.2	.03
LV Mass Volume (g/ml)	0.7	0.8	0.8	0.8	0.9	0.8	.26	0.8	0.8	0.7	0.7	.19
LV Mass Volume z score	−1.0	0.5	−0.3	−0.5	0.9	−0.4	.54	0.5	0.7	0.3	0.2	.28
ESFS (g/cm2)	99	89.5	115	115	114	122	.02	109	107.5	99	104	.97
ESFS z score	2.2	1.4	3.67	3.63	3.45	4.18	.02	3.3	3.1	2.3	2.8	.83
εcc (%)	−22.5	−20.3	−19.1	−18.1	−16.3	−18.9	.02	−21.1	−19.0	−19.3	− 19.9	.45
ειι (%)	− 19.1	−19.3	− 16.2	−15.8	− 14.7	−17.4	.02	−18.0	− 16.0	−15.5	− 16.4	.56

LV left ventricular, CMR cardiac magnetic resonance imaging, n number of subjects, AC anthracycline, EF ejection fraction, EDVI end diastolic volume index, ESVI end systolic volume index, SV stroke volume, ESFS end systolic fiber stress; εcc peak global circumferential strain magnitude; ειι: Peak global longitudinal strain magnitude. All patients in the low dose group had diagnosis of leukemia or lymphoma with Anthracycline cumulative doses of 175.2 ± 21.4 compared to 447.3 ± 4.6 (p < .0001) in the high dose group (solid tumor diagnosis)

Bold numbers indicate statistically significant cardiac magnetic resonance imaging parameters