Table 3.
Variables, measures, and sources of data
| Variables | Measures | Sources |
|---|---|---|
| Primary efficacy outcomes | ||
| Delayed recall memory | Hopkins Verbal Learning Test-Revised52,53 delayed recall (parallel versions) | Patient |
| Serum BDNF | Serum | Patient |
| Secondary efficacy outcomes | ||
| Working memory | CogState Health One Back Accuracy Task54,55 | Patient |
| Instrumental activities of daily living | Everyday Problems Test – Cognitively Challenged Version56 | Patient |
| Health-related quality of life | Minnesota Living with Heart Failure Questionnaire2,57 | Patient |
| Cost-effectiveness - resource use | Cardiology and other outpatient clinic visits, emergency department visits, ambulance services, hospitalizations, procedures, laboratory tests, medications, outpatient treatments, home care | Electronic health record |
| Cost-effectiveness – quality adjusted life years | Health Utilities Index Mark-358,82 | Patient |
| Potential moderating variables | ||
| Depressive symptoms | Patient Health Questionnaire-82,59 | Patient |
| BDNF gene Val66Met polymorphism | N/A | Patient |
| APOE-ε4 allele | N/A | Patient |
| Blocking variables | ||
| Global cognitive function | Montreal Cognitive Assessment test27 | Patient |
| Gender | N/A | Patient |
| Sample description variables/Covariates | ||
| Demographics | Demographics form | Patient |
| HF etiology, duration, BNP, devices, medications | N/A | Electronic health record |
| Medical comorbidities | Charlson Comorbidity Index83 | Electronic health record |
| Daytime sleepiness | Epworth Sleepiness Scale84 | Patient |
| Balance | Timed-Up-and-Go test85 | Patient |
| Fall history | Falls assessment questionnaire | Patient |
| Premorbid intellect | Wide Range Achievement Test, 4th ed. Reading86 | Patient |
| Memory-Visual recognition | CogState Health One Card Learning Task54,55 | Patient |
| Attention and psychomotor function | CogState Health Identification and Detection tasks;54,55 Digit Symbol Subtest87 | Patient |
| Executive function | Category fluency (animal, vegetable)88 Stroop test89 | Patient |
| Intervention fidelity variables | ||
| Time spent each session | Computer program and calendar | Computer, Patient |
| Mental effort after each session | Mental effort questionnaire | Patient |
| Change in clinical condition | Clinical change rating scale76 | Patient |
| Patient satisfaction with program | Patient Satisfaction Questionnaire90 | Patient |
APOE, apolipoprotein; BDNF, brain-derived neurotrophic factor; BNP, brain-natriuretic peptide; HF, heart failure