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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Semin Cell Dev Biol. 2017 Dec 11;82:41–50. doi: 10.1016/j.semcdb.2017.11.006

Figure 2. Nuclear movements in 2D migrating fibroblasts.

Figure 2

A. Nuclear translocation mediated by MTs. Nuclear dynein and dynactin engage centrosomal MTs to move the nucleus toward the centrosome. Centrosome position is maintained by cortically anchored dynein and dynactin. B: Nuclear translocation mediated by actomyosin tension. Lamellipodial protrusion generates actomyosin tension that pulls the nucleus forward. Tension is coupled to the nucleus through undefined LINC complexes (see text). C. Nuclear positioning mediated by perinuclear localized FMN2 adhesions. D. Nuclear rotation mediated dynein and dynactin. Cortically anchored dynein and dynactin maintain the position of the centrosome. E. Nuclear reorientation mediated by the actin cap. Actin fibers comprising the actin cap are anchored by focal adhesions at each end and are connected to the nucleus by undefined LINC complexes (see text). Black arrows: direction of the nuclear movement. Red molecules/structures: elements responsible for the nuclear movement.