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. Author manuscript; available in PMC: 2019 Jun 27.
Published in final edited form as: Vaccine. 2018 May 31;36(28):4095–4101. doi: 10.1016/j.vaccine.2018.05.086

Table 1.

HAI titers against the WT and X179A strains pre- and post-vaccination.1

Experiment 1 Experiment 2
Pre-vaccination Post-vaccination Pre-vaccination Post-vaccination
Study ID Age (years) WT X179A X179A/WT WT X179A X179A/WT WT X179A X179A/WT WT X179A X179A/WT Infecte d2
1 49 10 30 3 10 30 3 10 30 3 10 30 3
2 18 160 160 1 320 480 1.5 160 120 0.75 320 240 0.75
3 46 5 5 1 5 5 1 5 10 2 5 10 2
4 35 5 5 1 10 10 1 5 5 1 10 5 0.5
5 40 40 30 0.75 40 30 0.75 30 20 0.67 30 30 1
6 40 40 30 0.75 40 30 0.75 40 30 0.75 40 30 0.75
7 49 20 30 1.5 60 60 1 20 20 1 40 60 1.5
8 17 30 30 1 120 80 0.67 30 20 0.67 120 80 0.67
9 47 80 60 0.75 120 120 1 80 80 1 160 120 0.75
10 21 240 240 1 240 160 0.67 240 160 0.67 240 160 0.67
11 19 20 20 1 60 40 0.67 20 10 0.5 40 30 0.75
12 48 5 5 1 5 5 1 5 5 1 5 5 1
13 48 240 480 2 240 320 1.33 240 480 2 160 320 2
14 18 20 40 2 30 60 2 10 40 4 20 60 3
15 53 5 5 1 5 5 1 5 5 1 5 5 1
16 44 5 5 1 10 10 1 5 5 1 5 10 2
17 41 5 5 1 30 30 1 5 5 1 30 20 0.67
18 46 5 5 1 30 30 1 5 5 1 30 20 0.67
19 48 5 5 1 5 5 1 5 5 1 5 5 1
20 49 5 5 1 5 5 1 5 5 1 5 5 1
21 17 480 480 1 320 240 0.75 320 480 1.5 160 320 2
22 45 320 240 0.75 240 240 1 160 240 1.5 240 240 1
23 59 40 40 1 30 30 1 30 40 1.33 20 30 1.5
24 20 240 240 1 160 160 1 160 240 1.5 160 160 1
25 53 10 10 1 30 30 1 10 10 1 30 30 1
26 56 40 5 0.13 60 20 0.33 40 5 0.13 60 20 0.33
27 43 20 60 3 10 60 6 10 60 6 20 80 4
28 40 30 40 1.33 20 30 1.5 20 40 2 20 30 1.5
29 38 60 40 0.67 60 30 0.5 40 40 1 40 30 0.75
30 42 5 10 2 5 30 6 5 20 4 5 30 6
31 42 40 60 1.5 40 60 1.5 30 40 1.33 40 40 1
32 38 40 30 0.75 40 60 1.5 30 30 1 40 40 1
33 37 20 30 1.5 20 30 1.5 20 30 1.5 10 20 2
34 38 40 40 1 40 40 1 30 40 1.33 40 40 1
35 39 40 30 0.75 60 40 0.67 40 30 0.75 60 40 0.67
36 16 320 240 0.75 640 480 0.75 240 160 0.67 320 320 1
37 44 60 60 1 60 60 1 60 60 1 40 40 1
38 46 30 20 0.67 20 10 0.5 20 20 1 20 20 1
39 52 5 5 1 5 5 1 5 5 1 5 5 1
40 47 20 10 0.5 20 20 1 10 20 2 20 20 1
41 43 5 5 1 30 30 1 5 10 2 30 30 1
42 41 10 10 1 20 30 1.5 10 20 2 20 30 1.5
43 51 160 120 0.75 160 120 0.75 160 120 0.75 120 120 1
44 40 60 40 0.67 40 30 0.75 40 40 1 40 40 1
45 43 5 120 24 20 240 12 5 120 24 20 240 12
46 69 5 5 1 5 5 1 5 5 1 5 5 1
47 46 40 80 2 60 120 2 40 60 1.5 80 80 1
48 46 5 5 1 5 5 1 5 5 1 5 5 1
49 33 60 60 1 80 60 0.75 60 40 0.67 80 60 0.75
50 41 20 20 1 20 20 1 20 20 1 20 20 1
51 46 80 60 0.75 80 80 1 80 60 0.75 80 60 0.75
52 17 640 480 0.75 640 480 0.75 480 320 0.67 640 480 0.75
53 15 480 320 0.67 480 320 0.67 320 240 0.75 320 320 1
54 44 10 5 0.5 10 5 0.5 5 5 1 5 5 1
55 52 20 20 1 30 30 1 20 20 1 30 20 0.67
56 19 120 120 1 80 60 0.75 120 80 0.67 80 60 0.75
57 41 120 60 0.5 120 80 0.67 80 60 0.75 80 60 0.75
58 43 20 30 1.5 320 480 1.5 20 30 1.5 320 320 1
59 41 20 10 0.5 20 20 1 20 10 0.5 20 20 1
60 51 5 5 1 30 40 1.33 5 5 1 30 30 1
61 50 10 10 1 20 20 1 10 20 2 10 20 2
62 44 80 60 0.75 80 80 1 80 40 0.5 80 60 0.75
63 38 5 5 1 20 30 1.5 5 5 1 20 30 1.5
64 17 240 240 1 240 240 1 240 160 0.67 240 160 0.67
65 50 30 40 1.33 5 5 1 10 40 4 5 5 1
66 53 20 10 0.5 30 30 1 20 5 0.25 30 20 0.67
67 46 60 40 0.67 120 120 1 40 30 0.75 80 60 0.75
68 54 80 60 0.75 30 40 1.33 60 40 0.67 30 20 0.67
69 36 160 120 0.75 320 240 0.75 120 80 0.67 320 160 0.5
70 42 10 20 2 30 30 1 20 20 1 20 20 1
71 45 120 120 1 160 160 1 120 80 0.67 120 80 0.67
72 34 240 120 0.5 320 160 0.5 240 120 0.5 320 160 0.5
73 47 30 20 0.67 20 10 0.5 20 10 0.5 20 10 0.5
74 42 5 5 1 20 10 0.5 5 5 1 20 10 0.5
75 20 160 120 0.75 240 240 1 160 80 0.5 320 160 0.5
76 17 120 120 1 160 120 0.75 160 80 0.5 160 80 0.5
77 35 320 240 0.75 480 320 0.67 320 160 0.5 320 160 0.5
78 38 240 240 1 160 160 1 240 160 0.67 160 120 0.75
79 39 30 30 1 30 40 1.33 20 30 1.5 30 40 1.33
80 44 160 120 0.75 160 120 0.75 160 80 0.5 160 80 0.5
81 41 10 20 2 30 120 4 10 10 1 20 80 4
82 44 30 30 1 40 40 1 30 20 0.67 30 30 1 +
83 50 5 5 1 5 5 1 5 5 1 5 5 1
84 19 120 80 0.67 160 120 0.75 120 80 0.67 160 120 0.75
85 42 10 10 1 20 10 0.5 10 10 1 20 10 0.5
86 40 30 30 1 40 30 0.75 30 30 1 40 30 0.75
87 66 30 30 1 30 30 1 30 30 1 20 30 1.5
88 50 5 5 1 5 5 1 5 5 1 5 5 1
89 36 40 40 1 40 40 1 40 40 1 40 30 0.75
90 43 5 5 1 40 40 1 5 5 1 40 40 1 +
91 46 5 10 2 30 40 1.33 5 5 1 20 30 1.5
92 41 5 5 1 5 5 1 5 5 1 5 5 1
93 47 10 30 3 10 40 4 10 40 4 10 40 4
94 41 80 60 0.75 40 30 0.75 80 80 1 40 20 0.5
95 39 5 5 1 5 5 1 5 5 1 5 5 1
96 42 80 80 1 80 60 0.75 80 60 0.75 80 40 0.5
97 41 60 120 2 40 80 2 40 80 2 40 80 2
98 54 5 5 1 320 320 1 5 5 1 320 240 0.75
99 46 5 10 2 5 20 4 5 10 2 5 10 2
100 47 40 40 1 30 40 1.33 30 40 1.33 30 30 1
101 49 20 10 0.5 10 10 1 20 5 0.25 10 5 0.5
102 20 240 240 1 240 240 1 240 160 0.67 240 160 0.67
103 20 640 640 1 640 640 1 640 640 1 480 320 0.67
104 17 640 480 0.75 480 480 1 480 320 0.67 480 320 0.67
105 41 40 60 1.5 40 60 1.5 30 40 1.33 40 40 1
106 39 5 20 4 10 30 3 5 10 2 10 20 2
107 43 60 60 1 60 60 1 40 40 1 40 40 1
108 45 5 5 1 5 5 1 5 5 1 5 5 1 +
109 49 120 120 1 120 120 1 80 80 1 80 80 1
110 50 30 120 4 60 120 2 30 120 4 40 80 2
111 62 5 5 1 5 5 1 5 5 1 5 5 1
112 78 5 5 1 5 5 1 5 5 1 5 5 1
113 18 120 80 0.67 120 80 0.67 80 60 0.75 80 60 0.75
114 53 5 30 6 10 40 4 5 20 4 10 40 4
115 50 60 60 1 60 80 1.33 60 40 0.67 60 60 1
116 22 240 240 1 120 120 1 240 160 0.67 160 120 0.75
117 19 80 80 1 80 60 0.75 80 60 0.75 80 40 0.5
118 47 20 40 2 30 60 2 20 30 1.5 30 40 1.33
119 78 5 5 1 5 10 2 5 5 1 5 5 1
120 75 5 5 1 10 20 2 5 5 1 5 10 2
121 42 80 60 0.75 80 60 0.75 80 60 0.75 80 60 0.75
122 38 80 80 1 120 120 1 80 60 0.75 80 80 1
123 57 5 5 1 5 10 2 5 5 1 5 5 1
124 40 40 60 1.5 80 120 1.5 40 40 1 60 60 1
125 40 5 10 2 30 30 1 5 10 2 20 20 1
126 41 160 160 1 160 160 1 160 120 0.75 160 120 0.75
127 34 20 30 1.5 30 40 1.33 20 20 1 20 30 1.5
128 16 40 30 0.75 120 120 1 40 30 0.75 120 80 0.67
129 38 20 30 1.5 30 30 1 20 20 1 30 30 1
130 40 60 60 1 60 60 1 40 60 1.5 40 60 1.5
131 44 5 10 2 5 30 6 5 30 6 5 30 6 +
132 47 5 5 1 40 60 1.5 5 5 1 40 40 1
133 43 40 30 0.75 40 30 0.75 40 30 0.75 30 20 0.67
134 28 120 80 0.67 120 120 1 80 60 0.75 120 80 0.67
135 44 10 10 1 20 20 1 10 5 0.5 20 10 0.5
136 45 120 120 1 120 120 1 120 80 0.67 160 120 0.75
137 49 40 40 1 30 40 1.33 40 30 0.75 30 30 1 +
138 52 30 20 0.67 30 30 1 20 20 1 20 20 1 +
139 46 480 320 0.67 480 240 0.5 480 240 0.5 320 160 0.5
140 40 5 20 4 10 30 3 5 10 2 10 20 2
141 43 240 240 1 240 240 1 160 160 1 160 160 1
142 44 40 30 0.75 20 10 0.5 40 20 0.5 20 10 0.5
143 45 10 10 1 30 30 1 10 5 0.5 20 10 0.5
144 16 320 240 0.75 480 480 1 320 240 0.75 480 240 0.5
145 51 20 20 1 160 120 0.75 20 10 0.5 160 120 0.75
146 54 10 40 4 30 60 2 10 30 3 30 40 1.33
147 36 5 5 1 10 80 8 5 5 1 10 60 6
148 38 40 40 1 60 60 1 40 30 0.75 60 40 0.67 +
149 38 10 20 2 20 30 1.5 10 10 1 20 20 1
150 41 10 5 0.5 40 30 0.75 5 5 1 40 20 0.5
151 19 5 5 1 160 160 1 5 5 1 480 120 0.25
152 49 60 40 0.67 80 60 0.75 60 40 0.67 80 40 0.5
153 52 40 30 0.75 60 60 1 30 20 0.67 40 40 1
154 52 5 5 1 40 30 0.75 5 5 1 40 20 0.5
155 35 40 40 1 40 40 1 40 80 2 40 60 1.5
156 46 20 40 2 120 240 2 10 40 4 80 160 2
157 43 40 30 0.75 80 60 0.75 40 20 0.5 80 40 0.5
158 44 5 5 1 5 5 1 5 5 1 5 5 1
159 53 5 5 1 5 5 1 5 5 1 5 5 1
1

Grey indicates post-vaccination sera samples that had 4-fold higher HAI titers using X179A virus compared to WT virus in 2 independent experiments. Undetectable titers were assigned a value of 5.

2

The infected column indicates whether the donor was infected after vaccination during the 2015-2016 influenza season.