Table 3.
Factors Associated with Survival in HCC Patients with Extrahepatic Spread or Macrovascular Invasion.
| Variable | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | (95% CI) | p value | HR | (95% CI) | p value | ||
| Age | ≥70 | 0.84 | (0.46-1.51) | 0.55 | 1.60 | (0.82-3.17) | 0.17 |
| Sex | Male | 1.37 | (0.69-3.03) | 0.38 | 1.08 | (0.49-2.56) | 0.86 |
| Child-Pugh score | 5 | 0.57 | (0.32-1.03) | 0.06 | 0.58 | (0.30-1.13) | 0.11 |
| HBV | yes | 0.81 | (0.33-1.70) | 0.59 | |||
| HCV | yes | 1.27 | (0.69-2.47) | 0.45 | |||
| Extrahepatic spread | yes | 1.22 | (0.64-2.54) | 0.55 | |||
| Lung | yes | ||||||
| Bone | yes | 1.45 | (0.78-2.63) | 0.24 | |||
| Lymph node | yes | 0.9 | (0.47-1.64) | 0.73 | |||
| Adrenal gland | yes | 1.85 | (0.63-4.33) | 0.24 | |||
| Macrovascular invasion | yes | 1.22 | (0.66-2.20) | 0.52 | |||
| Concomitant intrahepatic lesions | no | 1.51 | (0.72-3.70) | 0.29 | |||
| AFP (ng/mL) | ≥400 | 2.35 | (1.08-4.81) | 0.03 | 3.82 | (1.64-8.67) | <0.01 |
| DCP (mAu/mL) | ≥1,000 | 1.5 | (0.78-2.76) | 0.22 | |||
| Combination of sorafenib and radiotherapy | yes | 0.25 | (0.10-0.54) | <0.01 | 0.20 | (0.12-0.61) | <0.01 |
HR: hazard ratio, CI: confidence interval, HBV: hepatitis B, HCV: hepatitis C, AFP: α-fetoprotein, DCP: des-γ-carboxy prothrombin