TABLE 3.
Multivariate Logistic Regression Analysis of Risk Factors for Each CCA Subtype
| Variables | iCCA (n = 1169)
|
pCCA (n = 995)
|
dCCA (n = 231)
|
|||
|---|---|---|---|---|---|---|
| AOR (95% CI) | P | AOR (95% CI) | P | AOR (95% CI) | P | |
| Age, per 10-year increase | 1.17 (1.09-1.25) | <0.001 | 1.36 (1.26-1.47) | <0.001 | 1.22 (1.04-1.43) | 0.01 |
| Gender, female | 1.13 (0.95-1.33) | 0.2 | 1.13 (0.94-1.37) | 0.2 | 1.31 (0.89-1.91) | 0.2 |
| Race, white | 0.93 (0.63-1.36) | 0.7 | 0.68 (0.44-1.03) | 0.07 | 0.89 (0.34-2.34) | 0.8 |
| PSC | 93.4 (27.1-322.2) | <0.001 | 453 (104-999) | <0.001 | 34.0 (3.57-323.1) | 0.002 |
| Biliary tract diseases | 7.60 (2.34-24.66) | 0.001 | 42.3 (1.57-999) | 0.03 | * | * |
| Non-PSC-related cirrhosis† | 13.8 (6.62-28.63) | <0.001 | 14.1 (5.87-33.7) | <0.001 | 3.40 (0.55-21.15) | 0.2 |
| HBV infection | 12.9 (2.69-61.61) | 0.001 | 0.17 (0.02-1.26) | 0.08 | 1.32 (0.01-196.9) | 0.9 |
| HCV infection | 1.95 (0.75-5.11) | 0.2 | 3.51 (1.02-12.08) | 0.047 | 0.17 (0.01-5.17) | 0.3 |
| IBD | 1.32 (0.74-2.33) | 0.4 | 1.31 (0.68-2.53) | 0.4 | 4.32 (0.97-19.26) | 0.06 |
| Diabetes | 2.50 (1.95-3.20) | <0.001 | 2.88 (2.19-3.78) | <0.001 | 4.22 (2.54-6.99) | <0.001 |
| Obesity | 0.77 (0.64-0.92) | 0.005 | 1.13 (0.92-1.40) | 0.2 | 0.69 (0.45-1.06) | 0.09 |
| NAFLD/NASH | 1.40 (0.94-2.09) | 0.1 | 0.61 (0.36-1.04) | 0.07 | 2.33 (0.97-5.59) | 0.06 |
| Smoking, ever-smoker | 1.21 (1.02-1.43) | 0.03 | 1.25 (1.03-1.52) | 0.02 | 1.85 (1.27-2.71) | 0.001 |
| Aspirin, current user | 0.35 (0.29-0.42) | <0.001 | 0.34 (0.27-0.42) | <0.001 | 0.29 (0.19-0.44) | <0.001 |
*
Not able to estimate.
†
Defined as a cirrhotic condition without existing PSC.
Abbreviations: NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis.