Table 2.
Protective Effect of Benzylamine Analogues of 1 to Ameliorate Etoposide-Induced Apoptosis in PC12 Cells (n = 3, Percentage Cell Viability Represented As Mean ± SEM)
| |||
|---|---|---|---|
| Compound | R | % Viability (3 μM) | MPO Score |
| Vehicle | 52.13 ± 1.13 | ||
| 1 |
|
79.50 ± 3.22 | 4.50 |
| 9a |
|
64.32 ± 2.47 | 4.44 |
| 9b |
|
78.63 ± 6.27 | 4.50 |
| 9c |
|
82.76 ± 2.15 | 4.30 |
| 9d |
|
68.17 ± 3.05 | 4.30 |
| 9e |
|
68.38 ± 3.67 | 4.30 |
| 9f |
|
81.57 ± 6.54 | 4.10 |
| 9g |
|
80.59 ± 1.90 | 3.67 |
| 9h |
|
79.24 ± 13.63 | 3.56 |
| 9i |
|
135.53 ± 12.27 | 4.48 |
| 9j |
|
82.28 ± 12.82 | 4.48 |
| 9k |
|
79.68 ± 6.13 | 4.22 |
| 9l |
|
87.49 ± 6.13 | 4.22 |
| 9m |
|
72.94 ± 5.41 | 4.14 |
| 9n |
|
75.70 ± 3.69 | 3.41 |
| 9o |
|
78.04 ± 7.51 | 4.50 |
| 9p |
|
87.89 ± 4.66 | 4.23 |
| 9q |
|
48.88 ± 3.91 | 3.90 |
| 9r |
|
76.08 ± 7.37 | 3.96 |
| 9s |
|
57.59 ± 3.67 | 4.24 |
| 9t |
|
59.29 ± 5.17 | 4.50 |
| 9u |
|
49.96 ± 3.71 | 4.50 |
| 9v |
|
66.17 ± 2.76 | 4.50 |
| 14 |
|
69.94 ± 4.27 | 4.62 |
| 15 |
|
88.74 ± 5.53 | 5.00 |