Skip to main content
. Author manuscript; available in PMC: 2018 Jun 12.
Published in final edited form as: J Med Chem. 2017 Nov 22;60(23):9739–9756. doi: 10.1021/acs.jmedchem.7b01199

Table 4.

Protective Effect of Hybrid Analogues of 1 to Ameliorate Etoposide-Induced Apoptosis in PC12 Cells (n = 3, Percentage Cell Viability Represented As Mean ± SEM)

Compound Structure % Viability (3 μM) MPO Score
Vehicle 52.13 ± 1.13
1 graphic file with name nihms970757t40.jpg 79.50 ± 3.22 4.50
10 graphic file with name nihms970757t44.jpg 41.28 ± 5.84 4.48
11 graphic file with name nihms970757t45.jpg 107.25 ± 1.33 4.06
12 graphic file with name nihms970757t46.jpg 79.65 ± 3.06 4.25
13 graphic file with name nihms970757t47.jpg 107.50 ± 4.23 2.99
21 graphic file with name nihms970757t48.jpg 63.99 ± 3.21 4.68
22 graphic file with name nihms970757t49.jpg 64.27 ± 7.19 4.87
23 graphic file with name nihms970757t50.jpg 67.50 ± 7.60 5.00
28 graphic file with name nihms970757t51.jpg 91.62 ± 6.35 3.71
29 graphic file with name nihms970757t52.jpg 55.56 ± 4.28 4.39
30 graphic file with name nihms970757t53.jpg 60.13 ± 6.59 3.73