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. 2018 Jun 11;9:2281. doi: 10.1038/s41467-018-04500-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — V2 feedback controls response amplitude in the sRF and proximal surround. a, b Changes in proximal surround-suppression with V2 feedback inactivated. a Bottom: response with and without laser for stimuli involving the sRF and proximal surround (i.e., stimulus size corresponding to the peak of the laser-on curve). Top: Cell-by-cell percent response change caused by laser stimulation, for stimuli involving the sRF and proximal surround. Downward and upward stem: decreased and increased response, respectively. b Suppression Index (SI; see Methods) with and without laser for stimuli extending into the proximal surround. SI = 1 indicates maximal suppression, SI = 0 indicates no suppression, and negative SI values indicate facilitation. c Same as b but for stimuli extending into the distal surround (largest stimulus used). d Bottom: response with and without laser for stimuli matched in size to the sRF diameter (i.e., the stimulus diameter at the peak of the empirically measured, spatial-summation curve in the no-laser condition). Top: Cell-by-cell percent response change caused by laser stimulation for stimuli matched to the sRF diameter. Arrows: means. One data point with very high firing rate in the scatterplots of panels a–d was removed for visualization purpose, but it was included in the analysis. Dashed line in a–d: unity line