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. 2018 Jun 11;9:2282. doi: 10.1038/s41467-018-04558-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Identification of genes and DNAm sites associated with four brain-related traits. Genes (DNAm sites) associated with the brain-related traits were identified by a SMR analysis of GWAS data with eQTL (mQTL) data from brain and blood samples. The four brain-related traits are smoking, IQ, SCZ, and EduYears. a, c show the number of genes (DNAm sites) with at least one significant SNP at P < 5 × 10⁻⁸ in different data sets. b, d show the number of genes (DNAm sites) associated with traits identified in different data sets. Sample sizes of the brain studies: GTEx-brain (n = ~233), CMC (n = 467), ROSMAP (n = 494), Brain-eMeta (n_eff = ~1194), and Jaffe et al. (n = 526). Sample sizes of the blood studies: CAGE (n = 2765), eQTLGen (n = 14,115), LBC + BSGS (n = 1980)