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. 2018 Jun 11;8:8798. doi: 10.1038/s41598-018-27192-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Projection artifacts in confluent hyperreflective foci within the HFL in a 60-year-old patient with moderate NPDR. The 10-μm-thick en-face OCTA (A) and structural OCT (B) images in the HFL between the red lines in panel D. (C) OCTA image in the superficial layer. (D,E) B-scan images without and with decorrelation signals along the green arrow in panel F. (F) The merged image (grayscale = structural OCT, red = OCTA) within a central 3 × 3 mm in the HFL. (G) The magnified image within the square in panel F. The decorrelation signal appears to be a meshwork-like capillary network. (H) The merged image of OCTA in the superficial layer (green) and HFL (red). (I) The magnified image within the square in panel H shows that the decorrelation signals in hyperreflective foci correspond to projection artifacts. Scale bar = 500 μm.