Table 3.

Lead genome-wide significant SNP for each independent locus identified in the UK Biobank and replication in GERA

SNP	Chr	Pos	Locus	Alleles	UKB discovery cohort		GERA replication cohort
					OR (95% CI)	P	OR (95% CI)	P
rs2814471	1	165739598	TMCO1	C/T	1.39 (1.32–1.45)	7.5 × 10−44	1.34 (1.26–1.43)	2.0 × 10−20
rs56335522	2	213758234	near IKZF2	G/C	1.18 (1.11–1.25)	1.7 × 10−8	1.20 (1.11–1.29)	2.0 × 10−6
rs34201102	3	85137499	CADM2	A/G	1.11 (1.08–1.15)	6.1 × 10−10	1.10 (1.05–1.15)	2.1 × 10−5
rs9853115	3	186131600	near DGKG	T/A	1.11 (1.07–1.15)	1.7 × 10−9	1.10 (1.05–1.14)	2.2 × 10−5
rs9330348	4	7883887	AFAP1	C/G	1.16 (1.12–1.20)	2.4 × 10−18	1.15 (1.10–1.20)	5.7 × 10−10
rs76325372	5	14837332	ANKH	A/C	1.14 (1.09–1.18)	1.4 × 10−10	1.09 (1.04–1.14)	0.00045
rs2073006	6	637465	EXOC2	C/T	0.86 (0.82–0.90)	2.8 × 10−10	0.86 (0.81–0.92)	1.2 × 10−6
rs12699251	7	11679113	THSD7A	A/G	0.90 (0.87–0.93)	1.5 × 10−9	0.95 (0.90–0.99)	0.017
rs6969706	7	116154831	CAV1/CAV2	G/T	0.90 (0.86–0.93)	8.4 × 10−9	0.91 (0.87–0.95)	9.6 × 10−5
rs2514884	8	108276873	ANGPT1	C/T	0.84 (0.80–0.88)	1.4 × 10−11	0.93 (0.87–0.98)	0.014
rs1333037	9	22040765	CDKN2B-AS1	C/T	0.84 (0.81–0.87)	2.4 × 10−23	0.77 (0.74–0.81)	2.9 × 10−29
rs2472493	9	107695848	near ABCA1	G/A	1.15 (1.12–1.19)	6.3 × 10−17	1.17 (1.12–1.22)	1.2 × 10−13
rs55770306	9	129388033	LMX1B	C/A	0.86 (0.83–0.90)	5.5 × 10−14	0.90 (0.85–0.95)	0.00019
rs2274224	10	96039597	PLCE1	G/C	0.91 (0.88–0.94)	3.1 × 10−8	0.96 (0.92–1.00)	0.058
rs12806740	11	120203628	TMEM136	G/A	0.90 (0.87–0.93)	3.8 × 10−9	0.93 (0.89–0.97)	0.0017
rs34935520	14	61091401	SIX1/SIX6	G/A	1.14 (1.10–1.17)	3.6 × 10−13	1.17 (1.12–1.22)	1.8 × 10−12
rs9913911	17	10031183	GAS7	A/G	1.17 (1.13–1.21)	2.2 × 10−17	1.22 (1.17–1.28)	1.5 × 10−18
rs58714937	22	19856710	near TXNRD2	C/T	1.15 (1.10–1.21)	8.3 × 10−9	1.15 (1.09–1.23)	2.6 × 10−6

P-values in bold achieved genome-wide level of significance (P < 5 × 10⁻⁸); loci that are underlined are novel

SNP single-nucleotide polymorphism, Chr chromosome, Pos position, OR odds ratio