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. 2018 Jun 11;8:8811. doi: 10.1038/s41598-018-27081-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Active TC10 rescues the loss of axons caused in Arhgef7-deficient neurons. (a) Dissociated hippocampal neurons were transfected at 6 h after plating with expression vectors for an shRNA against Arhgef7 (Arhgef7 RNAi) and GFP-TC10F34L or GFP (green). Transfected neurons were analyzed at 3 d.i.v. by staining with an anti-MAP2 (red, dendrites) and the Tau-1 (blue, axons) antibody. The scale bar is 20 μm. (b) The formation of axons was analyzed at 3 d.i.v. by counting the number neurons without an axon (0, black) with a single axon (1, gray), and with multiple axons (>1, white) (ANOVA, Student’s t-Test, **p < 0.01, n = 3 experiments with 50 neurons counted per condition).