Table 2.
Compound | IC50 (µM) for inhibition of parasite proliferation | ||||
---|---|---|---|---|---|
Dd2 parent | NITD609-RDd2-clone#2 | Fold difference | n | p | |
MMV000858 | 0.38 ± 0.02 | 2.94 ± 0.38 | 7.7 ± 0.1 | 4 | <0.001 |
MMV001059 | 0.72 ± 0.06 | 3.74 ± 0.31 | 5.2 0.1 | 5 | <0.001 |
MMV006239 | 0.24 ± 0.03 | 1.87 ± 0.17 | 7.8 ± 0.1 | 4 | <0.001 |
MMV020081 | 0.11 ± 0.01 | 0.42 ± 0.03 | 3.8 ± 0.1 | 5 | <0.001 |
MMV020136 | 0.52 ± 0.02 | 3.92 ± 0.28 | 7.6 ± 0.1 | 4 | <0.001 |
MMV020391 | 0.28 ± 0.02 | 2.76 ± 0.32 | 9.9 ± 0.1 | 4 | <0.001 |
MMV020520 | 0.32 ± 0.04 | 1.39 ± 0.15 | 4.3 ± 0.2 | 4 | <0.001 |
MMV020623 | 0.37 ± 0.03 | 2.12 ± 0.31 | 5.7 ± 0.2 | 4 | 0.001 |
MMV020710 | 0.098 ± 0.012 | 0.55 ± 0.03 | 5.6 ± 0.1 | 4 | <0.001 |
MMV085210 | 1.60 ± 0.07 | 6.8 ± 0.9 | 4.2 ± 0.1 | 4 | <0.001 |
MMV688980 | 1.12 ± 0.07 | 7.2 ± 0.6 | 6.4 ± 0.1 | 5 | <0.001 |
KAE609 | 0.0011 ± 0.0001 | 0.012 ± 0.001 | 11.6 ± 0.1 | 5 | <0.001 |
Chloroquine | 0.21 ± 0.02 | 0.22 ± 0.02 | 1.0 ± 0.1 | 6 | 0.8 |
Artemisinin | 0.017 ± 0.005 | 0.019 ± 0.005 | 1.1 ± 0.4 | 3 | 0.8 |
The IC50 values are averaged from those obtained in n experiments and are presented as mean ± SEM. The ‘fold difference’ is the IC50 value obtained for NITD609-RDd2-clone#2 divided by the IC50 value obtained for the Dd2 parent (shown as the mean ± SEM from the number of experiments indicated). The p values are derived from unpaired student t tests.