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. 2018 Jun 11;9:2274. doi: 10.1038/s41467-018-04718-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Group analysis of network inactivation. The number of nodes in the relevant networks is quantified after LTP induction with or without targeted inactivation and normalized relative to the control, fully active, condition. a Proportion of nodes recruited by perforant pathway stimulation in the ipsilateral HC under control conditions (100%) and after inactivation of the NAc, PFC, contralateral HC (cHC), and S1, as indicated in the x-axis. Analysis of variance across groups demonstrates no statistical differences (ANOVA, F_4,24 = 0.3641, p = 0.8317). b Proportion of nodes recruited in the NAc following targeted inactivation in the structures indicated in the x-axis. ANOVA demonstrates statistically significant differences between groups (F_4,24 = 4.841, p = 0.0053) and post-hoc Bonferroni test finds the only significant difference in NAc recruitment when the NAc is directly inactivated (p < 0.01), as expected from the experimental manipulation, but no effect under PFC, cHC, or S1 inactivation. c Proportion of nodes recruited in the PFC following targeted inactivation in the structures indicated in the x-axis. ANOVA demonstrates statistically significant differences between groups (F_4,24 = 6.416, p = 0.0012) and post-hoc Bonferroni test identifies strong reductions in both PFC (p < 0.01), expected from the experimental manipulation, but also NAc (p < 0.05), indicating the disintegration of the long-range HC-PFC-NAc network under NAc inactivation