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. 2018 Jun 11;8:8818. doi: 10.1038/s41598-018-27291-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic Analysis in the NS5B region of Genotype 1b HCV. The genetic distance was estimated using Kimura 2 parameters, and a phylogenetic tree was constructed based on the nucleotide sequences in the NS5B region using the maximum likelihood method adapted with best fit model (Kimura 2-parameter plus Gamma distributed with Invariant sites). The bootstrap values are indicated at each tree root. Sequences with A218 and C316 wild-type (n = 40), A218S mutant and C316 wild-type (n = 10), and A218S and C316N mutant HCV strains (n = 59) observed in 109 sofosbuvir (SOF)-naïve patients are shown in blue, orange and black, respectively. Also, HCV strains (n = 7) detected in patients experiencing virologic failure after SOF-based therapy are shown in red.