Figure 4.

The role of Warburg effect on glycolytic tumor variables. (A) The Warburg effect tends to reduce tumor size. (B) Increasing p_G to values below 20 has little influence on proliferative cell count. Proliferative cell count tends to reduce for $p_G\ge 40$. (C) The number of quiescent cells decreases due to the consumption of oxygen by cancer cells. (D) Dead cell count exhibits an initial increase as p_G increases to a certain value and drops afterwards. (E–G) Proliferative and quiescent cells constitute a smaller fraction of the tumor as the glucose uptake is upregulated and dead cells tend to replace the proliferative and quiescent cells in the body of tumor. Fluctuations in population curves are more intense at higher values of p_G.