. 2018 Apr 30;9(11):2024–2029. doi: 10.7150/jca.24714

Table 2.

Univariate and Multivariate analysis of clinicopathological factors in relation to OS

Variables	No.	Univariate analysis			Multivariate analysis
Variables	No.	mOS (95%CI)	HR (95%CI)	p-value	HR (95%CI)	p-value
Age
≥ 65	46	12.00 (10.39-13.61)	0.69 (0.48-.098)	0.040	1.02 (0.69-1.51)	0.922
< 65	269	14.27 (11.93-16.61)	0.69 (0.48-.098)	0.040	1.02 (0.69-1.51)	0.922
Gender
female	124	12.80 (9.59-16.00)	1.04 (0.78-1.38)	0.797
male	191	13.83 (11.41-16.25)	1.04 (0.78-1.38)	0.797
Preoperative KPS
≥ 70	203	16.17 (13.80-18.55)	1.43 (1.08-1.89)	0.012	1.19 (0.89-1.59)	0.247
< 70	112	11.56 (9.72-13.41)	1.43 (1.08-1.89)	0.012	1.19 (0.89-1.59)	0.247
Pathology
pGBM	257	13.30 (11.64-14.96)	0.89 (0.74-1.07)	0.199
sGBM	58	16.90 (10.03-23.77)	0.89 (0.74-1.07)	0.199
Size
≥ 5cm	175	13.83 (10.33-17.33)	1.20 (0.89-1.60)	0.229
< 5cm	107	13.00 (9.31-16.70)	1.20 (0.89-1.60)	0.229
Resection
GTR	196	14.70 (12.04-17.36)	1.40 (1.06-1.86)	0.019	1.22 (0.91-1.64)	0.180
non-GTR	109	11.33 (7.63-15.04)	1.40 (1.06-1.86)	0.019
Chemoradiotherapy
Complete	173	18.00 (15.07-20.94)	3.28 (2.45-4.41)	< 0.001	3.77 (2.76-5.14)	< 0.001
Incomplete	124	7.50 (5.47-9.53)	3.28 (2.45-4.41)	< 0.001	3.77 (2.76-5.14)	< 0.001
IDH-1 R132H
Mutant	77	19.93 (13.62-26.24)	1.91 (1.35-2.71)	< 0.001	2.54 (1.72-3.74)	< 0.001
Wild-type	238	12.30 (10.90-13.70)	1.91 (1.35-2.71)	< 0.001	2.54 (1.72-3.74)	< 0.001
ATRX
Loss	60	16.23 (12.16-20.30)	1.41 (0.98-2.03)	0.066
Expression	241	12.80 (11.42-14.18)	1.41 (0.98-2.03)	0.066
Fib
≥ 3.37	35	9.03 (4.77-13.29)	0.54 (0.35-0.83)	0.005	0.64 (0.41-1.00)	0.048
< 3.37	280	13.83 (11.70-15.96)	0.54 (0.35-0.83)	0.005	0.64 (0.41-1.00)	0.048