Table 2.
Univariate and multivariate analyses of acute exacerbation of interstitial lung disease (ILD) in patients with stage III non-small-cell lung cancer and ILD treated with chemoradiotherapy (n = 37)
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p-value | Odds ratio | 95% CI | p-value | |
| Sex (female vs. male) | 1.92 | 0.28-13.2 | 0.6443 | |||
| Age (≥75 years vs. <75 years) | 0.31 | 0.07-1.28 | 0.1734 | |||
| ECOG-PS (1 vs. 0) | 1.50 | 0.40-5.66 | 0.7384 | |||
| Smoking history (never vs. current or former smoker) | 4.07 | 0.38-43.4 | 0.3153 | |||
| ILD classification on CT (non-UIP vs. UIP pattern) | 0.10 | 0.017-0.56 | 0.0097 | 0.11 | 0.014-0.60 | 0.0095 |
| %VC (≥80 vs. <80) (n = 34) | 0.76 | 0.09-6.17 | 1.0000 | |||
| V20 (≥25 vs. <25) (n = 35) | 4.81 | 1.03-22.6 | 0.0776 | 3.61 | 0.043-1.43 | 0.1270 |
| The finding of lung volume loss or honeycombing (either or both vs. none) | 4.07 | 0.38-43.4 | 0.3153 | |||
AE, acute exacerbation; ILD, interstitial lung disease; NSCLC, non-small-cell lung cancer; ECOG PS, Eastern Cooperative Oncology Group performance score; CT, computed tomography; UIP, usual interstitial pneumonia; VC, vital capacity; CI, confidence interval