Table 4.
Univariate and multivariate analyses of overall survival in patients with stage III non-small-cell lung cancer and interstitial lung disease treated with chemoradiotherapy (n = 37)
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Relative risk | 95% CI | p-value | Relative risk | 95% CI | p-value | |
| Sex (female vs. male) | 0.94 | 0.22-2.79 | 0.9329 | |||
| Age (≥75 years vs. <75 years) | 0.88 | 0.35-2.04 | 0.7718 | 0.75 | 0.29-1.81 | 0.5358 |
| ECOG-PS (1 vs. 0) | 0.90 | 0.39-2.14 | 0.8085 | 1.09 | 0.45-2.73 | 0.8412 |
| Smoking history (never vs. current or former smoker) | 1.79 | 0.41-5.50 | 0.3544 | |||
| Clinical staging (IIIB vs. IIIA) | 0.81 | 0.35-1.88 | 0.6140 | |||
| Histology (squamous vs. non-squamous) | 0.72 | 0.30-1.69 | 0.4499 | |||
| ILD classification on CT (non-UIP vs. UIP pattern) | 0.080 | 0.022-0.26 | <0.0001 | 0.073 | 0.019-0.25 | <0.0001 |
| %VC (≥80 vs. <80) (n = 34) | 2.66 | 0.55-47.8 | 0.3207 | |||
| The finding of lung volume loss or honeycombing (either or both vs. nothing) | 2.77 | 0.41-11.2 | 0.1835 | |||
OS, overall survival; NSCLC, non-small-cell lung cancer; ILD, interstitial lung disease; ECOG PS, Eastern Cooperative Oncology Group performance score; CT, computed tomography; UIP, usual interstitial pneumonia; VC, vital capacity; CI, confidence interval